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Post-Polio Health (ISSN 1066-5331)

Vol. 29, No. 4, Fall 2013

Research Update:
Role of Oral Glutathione

Claire Z. Kalpakjian, PhD, MS, University of Michigan,
Department of Physical Medicine and Rehabilitation, Ann Arbor, Michigan

Glutathione is a powerful antioxidant and plays an important role in a number of cellular processes and the maintenance of cellular homeostasis associated with health and longevity. The goal of this pilot study was to examine the effectiveness of oral glutathione for improving health outcomes in persons with the late effects of poliomyelitis.

A total of 20 individuals who were between the ages of 50 and 65 with clinically identified post-poliomyelitis late effects and who were able to ambulate at least 100 feet, with or without assistive devices, enrolled in this study. The intervention was a three-month trial of twice-daily, oral, 1,000-mg glutathione supplements. This study involved four assessment periods across the three-month study period (two clinic visits, two home-based assessments).

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