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Post-Polio Health (ISSN 1066-5331)

Vol. 32, No. 4, Fall 2016

 

Is the Post-Polio Syndrome Associated with Chronic Poliovirus Infection?

The central message of our study is that post-polio syndrome might be associated with a chronic low-level poliovirus infection caused by the virus type that – at the time of the initial event – had infected each patient. That is, the possibility exists that poliovirus remains in a “quiescent state” in the body for a long period of time.

The conclusion is derived from the study of a cohort of Italian PPS patients (112) and their family members (51), together with non-polio controls (71), and aged polio survivors with “stable polio” (18). Nearly three quarters of PPS patients appear to harbor “poliovirus remnants” (in other words polioviral genomes and low-level virus activity), while survivors with stable polio very rarely harbor poliovirus.

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